An open-source, free comprehensive software that will allow biomedical scientists to precisely locate shape changes in their imaging studies. This software called Slicer Shape AnaLysis Toolbox (SlicerSALT), will enhance the intuitiveness and ease of use for such studies, as well as allow researchers to find shape changes with higher statistical power. Altogether this constitutes a crucial resource for the imaging field that will enable many and important new findings in biomedical imaging studies.
The SlicerSALT developers gratefully acknowledge funding for this project provided by NIH NIBIB R01EB021391 (Shape Analysis Toolbox for Medical Image Computing Projects) and R56EB021391 (Shape Analysis Toolbox: From Medical Images to Quantitative Insights of Anatomy), as well as the Slicer community.
Compute Point Distributed Models (PDM) using Spherical Harmonic Representation (SPHARM-PDM)
Run 4D regression in a collection of 3D PDMs associated to a linear variable (i.e. age)
Perform correspondence optimization using study-wise shape analysis
Fit skeletal representations (s-reps) to a collection of binary volumes
Compute image-based correspondence in binary volumes of non-spherical and complex topologies
Use advanced shape statistics for scientific hypothesis testing
Access all functionality through the graphical user interface
Perform command line batch processing
Perform shape space exploration and PCA analysis in Point Distributed Models